Asymmetric Hydroxylation of Enolates with NSuifonyloxaziridines
نویسنده
چکیده
Franklin A. Davis was born in Des Moines. Iowa. He recelved his B.S. degree in 1962 from the University of WiScOnsln and was granted e Ph.D. degree in 1966 from Syracuse University working under Donald C. Dimer. After two years with Michael J. S. Dewar as a Welch PoSMoctoral Fellow at the University of Texas he joined the facuity at Drexel University in 1968 where he is currently the George S. Sasin Professor of Organic Chemistry. I n 1980 he received Drexel University's Research Achievement Award and in 1982 the PhiladelDhia ACS Section Award. Dr. Davis' research Interests lie in the area of asymmetric synthesis. molecular recognMon.and new syntheticmethodspartkularlyrelatedtoenalF tioselective oxidations. me development of new methods for the regioand stereoselective fluorination of organic molecules is a recent focus
منابع مشابه
A facile process for the asymmetric synthesis of β-trifluoromethylated β-amino ketones via addition of ketone enolates to sulfinylimine.
An efficient method for the asymmetric synthesis of β-trifluoromethylated β-amino ketones via addition of ketone-derivative enolates to trifluoromethylated sulfinylimine has been developed, with good chemical yields and excellent diastereoselectivities. This practical method was also proved to be suitable for large-scale preparation.
متن کاملDiastereo- and Enantioselective Iridium-Catalyzed Allylation of Cyclic Ketone Enolates: Synergetic Effect of Ligands and Barium Enolates
We report asymmetric allylic alkylation of barium enolates of cyclic ketones catalyzed by a metallacyclic iridium complex containing a phosphoramidite ligand derived from (R)-1-(2-naphthyl)ethylamine. The reaction products contain adjacent quaternary and tertiary stereocenters. This process demonstrates that unstabilized cyclic ketone enolates can undergo diastereo- and enantioselective Ir-cata...
متن کاملTitanium enolates of thiazolidinethione chiral auxiliaries: versatile tools for asymmetric aldol additions.
[formula: see text] Asymmetric aldol additions using chlorotitanium enolates of thiazolidinethione propionates proceed with high diastereoselectivity for the "Evans" or "non-Evans" syn product depending on the nature and amount of the base used. With (-)-sparteine as the base, selectivities of 97:3 to > 99:1 were obtained for the Evans syn products with 2 equivalents of base and for the non-Eva...
متن کاملRecent developments in the use of catalytic asymmetric ammonium enolates in chemical synthesis.
Catalytic enantioselective transformations of carbonyl compounds via enolates that comprise the enolization and bond-forming step have received considerable attention within the synthetic organic chemistry community. Many of these methods have exploited the versatile properties of asymmetric Lewis acid complexes that display basic and/or acidic properties and have successfully lead to the devel...
متن کامل